Harnessing PCORnet to Study Comparative Effectiveness and Safety of Biologic Therapies

Project Summary

This PPRN demonstration project will use PCORnet to study comparative effectiveness and safety of biologic therapies for autoimmune and inflammatory conditions in children and adults. Given the substantial unmet need in the autoimmune and inflammatory conditions of interest, new therapies have been and are being rapidly developed that offer additional choices, but with very little comparative data on how to best use these treatments, and for whom.  The project will focus on patient-centered domains to determine treatment effectiveness in order for patients and clinicians to make better informed treatment decisions.

Project Aims

This project brings together five patient-powered networks (PPRNs) and 2 Clinical Data Research Networks to address two aims:  1) to evaluate short term and longer term events associated with biologics and non-biologic immunodulatory therapies available for the treatment of adult and pediatric inflammatory arthritis, psoriasis, bowel disease and vasculitis, and 2) to evaluate comparative effectiveness of medications for autoimmune and inflammatory conditions from disease-specific and generic patient-reported outcome (PRO) domains.

Grantee Institution: University of Alabama at Birmingham

Mid-South PI: Cecilia Chung, MD

Funding Source: PCORI

Participating Mid-South Sites: Vanderbilt University Medical Center, Greenway Health, University North Carolina at Chapel Hill, and Medical University of South Carolina

If you have any questions feel free to contact us via email at midsouthcdrn@vanderbilt.edu.